Synephrine 30

Whether you're an athlete or not, Synephrine 30, from Vitobest®, is your new ally for weight loss, fat burning, and achieving metabolic balance. Synephrine 30 contains in each capsule 30 mg of P-Synephrine, of 100% natural origin from the dry extract of bitter orange (Citrus aurantium)¹.

Vitobest® only uses natural extracts in its products and Synephrine 30 is no exception, as the P-Synephrine that comes from nature presents double the potency than other forms of synthetic P-Synephrine present in other products².

P-Synephrine has a quality that makes it a completely different compound than we can find in any other "fat burner" supplement. Unlike other existing stimulants on the market, P-Synephrine acts directly and exclusively on adipocytes, cells present in abdominal and visceral fat, without having an effect on the heart, blood vessels or nervous system^3,4.

This translates into⁵:

• Direct stimulation on fat tissue, increasing its use as an energy source and increasing body temperature and caloric expenditure.
• Action that can occur even at rest, without the need for physical activity, favoring metabolic flexibility.
• All this without palpitations, tremors, insomnia or feelings of nervousness like other "fat burners".
• Ideal for people intolerant to high doses of caffeine.

In addition, P-Synephrine, according to studies, enhances caloric expenditure in women if taken with meals, equaling that of men and can regulate appetite^6,7.

Vitobest® uses for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Bibliography:

¹Bitter Orange: National Center for Complementary and Integrative Health (May 2020)

²Sidney J. Stohs a, Harry G. Preuss b: Stereochemical and pharmacological differences between naturally occurring p-synephrine and synthetic p-synephrine. January 2012.

³Arch, J.R.S. β3-adrenoceptor agonists: Potential, pitfalls and progress. Eur. J. Pharmacol. 2002, 440, 99–107.

⁴Stohs, S.J.; Preuss, H.G.; Shara, M. A review of the human clinical studies involving citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int. J. Med. Sci. 2012, 9, 527–538.

⁵Maldonado, M.; Bracht, L.; de Sá-Nakanishi, A.; Corréa, R.; Comar, J.; Peralta, R.; Bracht, A. Actions of p-synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver. Cell Biochem. Funct. 2018, 36, 4–12

⁶Gougeon R, Harrigan K, Tremblay JF, Hedrei P, Lamarche M, Morais JA. Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium. Obes Res. 2005 Jul;13(7):1187-94.

⁷Zheng, X.; Guo, L.; Wang, D.; Deng, X. p-synephrine: A novel agonist for neuromedin U2 receptor. Biol. Pharm. Bull. 2014, 37, 764–770.