Super C 1000

The vitamin C it is an essential supplement in our daily health and nutrition. Its contribution is fundamental and necessary for optimal functioning of:

• The immune system, improving the activity and effectiveness of white blood cells⁶.
• Joint and bone health. It is an essential element in the assimilation and formation of collagen⁷.
• Provides energy and reduces fatigue.
• Contributes to improving iron absorption⁹.
• Vitamin C is an essential cofactor in numerous enzymatic reactions, for example in the biosynthesis of carnitine and neuropeptides.
• Powerful antioxidant⁸.
• Vitamin C is involved in more than 200 metabolic processes.

Is an extra contribution necessary?

Vitamin C is a nutrient that the body is not capable of producing and we need to provide it through food. The recommended daily dose is 60-95 mg per day. However, this is the minimum dose under normal conditions, in the case of stress, infections, exhaustion, convalescence or wear and tear situations, this dose is much higher, reaching up to 2.5 g per day¹.

Not all vitamin C's are the same.

The absorption of vitamin C directly depends on both the ingested dose and bioavailability. Super C 1000, from Vitobest®, is 100% Calcium L-Ascorbate, one of the most active forms of vitamin C. Calcium ascorbate contains calcium threonate, studies show that threonate increases the bioavailability of vitamin C.

Extended release and bioavailability.

To further increase their profits, the Super C 1000, from Vitobest®, goes in ergosphere microgranules:

• They provide excellent absorption and assimilation properties.
• More comfortable doses. They allow taking the doses at sufficiently spaced times so you don't have to take doses outside the house.
• Reduction of digestive discomfort and acidity.

Advantages of Super C 1000 Vitobest®:

• Improved efficacy due to slow and prolonged release, not losing active ingredient in the digestive tract.
• Fewer daily shots.
• Most suitable therapeutic response.
• The treatment is better followed due to the convenience in the dosage.
• The bioavailability is higher, which reduces unwanted effects.
• Much less gastric discomfort and heartburn.

Why is the dosage and extended release so important?

The absorption and efficacy of vitamin C directly depends on the ingested dose. If the intake is less than 100 mg per day, between 80% and 90% is absorbed, while if it is 200 mg per day, it is completely absorbed, reaching a plasma concentration of 80-90 μM. On the other hand, there is a progressive decrease in the absorption of vitamin C with doses greater than 500 mg, for example, when ingesting 3 g, only 40% is absorbed.

Super C 1000, from Vitobest®, thanks to the extended release provided by its microgranules, it is close to the constant 200 mg range, which is almost total absorption.

Also, being calcium ascorbate achieves much higher bioavailability.

Vitobest® used for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Product Claims:

• Vitamin C contributes to the normal functioning of the immune system.
• Vitamin C contributes to normal energy metabolism.
• Vitamin C contributes to the normal formation of collagen for the normal functioning of the bones.
• Vitamin C contributes to the normal functioning of the nervous system.
• Vitamin C contributes to normal psychological function.
• Vitamin C contributes to the protection of cells against oxidative damage.
• Vitamin C helps to reduce tiredness and fatigue.
• Vitamin C improves iron absorption.
• Vitamin C helps to regenerate the reduced form of vitamin E.

Bibliography:

¹M. Levine, S.C. Rumsey, R.C. Daruwala, J.B. Park and Y. Wang, Criteria and recommendations for vitamin C intake, J.A.M.A. 281 (1999), 1415–1423.

²M. Levine, C. Conry-Cantilena and Y. Wang et al., Vitamin C pharmacokinetics in healthy volunteers: evidence for a Recommended Dietary Allowance, Proc. Natl. Acad. Sci. USA 93 (1996), 3704–3709.

³J. King, Y. Wang, R.W. Welch, K.R. Dhariwal, C. Conry-Cantilena and M. Levine, Use of a new vitamin C-deficient diet in a depletion/repletion clinical trial, Am. J. Clin. Nutr. 65 (1997), 1434–1440.

⁴J.F. Graumlich, T.M. Ludden, C. Conry-Cantilena, L.R. Jr. Cantilena LR, Y. Wang and M. Levine, Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion, Pharmaceutical Research 14 (1997), 1133–1139.

⁵M. Levine, New concepts in the biology and biochemistry of ascorbic acid, N. Engl. J. Med. 314 (1986), 892–902.

⁶Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid. In: Harris JR, ed. Subcellular Biochemistry. Vol. 25. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York: Plenum Press; 1996:215-231.

⁷Cheng Y, Willett WC, Schwartz J, Sparrow D, Weiss S, Hu H. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol. 1998;147(12):1162-1174.

⁸Basili S, Tanzilli G, Mangieri E, et al. Intravenous infusion of ascorbic acid improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers. JACC Cardiovasc Interv. 2010;3(2):221-229.

⁹Johnston CS. Vitamin C. In: Erdman JWJ, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Ames, Iowa: Wiley-Blackwell; 2012:248-260.