Caffeine 200

Caffeine 200 from Vitobest® provides 200 mg of anhydrous caffeine per capsule. The potent stimulating effect of caffeine is immediately effective due to its rapid absorption.

Caffeine is a stimulating alkaloid belonging to the group of methylxanthines, exerting its effects on the central nervous system, muscles, and adipose tissue.

It stimulates the secretion of excitatory neurotransmitters such as dopamine or noradrenaline thanks to its action on two pathways; inhibiting the action of adenosine and the enzyme PDE (cyclic nucleotide phosphodiesterase)^1,2,3.

Caffeine is an antagonist of specific adenosine receptors in the central nervous system, blocking their function, which exerts an anxiolytic and sedative effect.

On the other hand, it inhibits the PDE enzyme, increasing levels of cAMP (cyclic adenosine monophosphate), which stimulates the release of excitatory neurotransmitters such as dopamine or noradrenaline. cAMP also stimulates LSH (hormone-sensitive lipase), an enzyme responsible for releasing fatty acids to be used as energy sources through mitochondrial oxidation in cells, reducing body fat percentage.

Caffeine promotes intracellular transport of calcium during muscle contraction, directly improving its contraction capacity, the number of recruited muscle fibers, and thus muscle strength and hypertrophy^4,5,6.

This bilateral effect enhances fatigue and pain tolerance. It contributes to improving alertness, mood, motivation, and memory, making it ideal for moments of increased mental demand and effort^7,8.

Less fatigue translates to more intense and prolonged workouts, favoring calorie consumption, mobilization, and metabolism of fatty acids. Less fat and more muscle. That's why Caffeine 200 from Vitobest® is the ideal supplement to take before your workout.

Bibliography:

¹Simone Cappelletti, Daria Piacentino, Gabriele Sani, Mariarosaria Aromatario Caffeine: cognitive and physical performance enhancer or psychoactive drug? Curr Neuropharmacol.(2015 Jan)

²^Kenneth A Jacobson, Zhan-Guo Gao, Pierre Matricon, Matthew T Eddy, Jens Carlsson Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines Br J Pharmacol.(2022 Jul)

³Fiani B, Zhu L, Musch BL, Briceno S, Andel R, Sadeq N, Ansari AZ The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function. Cureus.(2021-May-14)

⁴Black CD, Waddell DE, Gonglach AR Caffeine's Ergogenic Effects on Cycling: Neuromuscular and Perceptual Factors. Med Sci Sports Exerc.(2015-Jun)

⁵^Rousseau E, Ladine J, Liu QY, Meissner G Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds. Arch Biochem Biophys.(1988-Nov-15)

⁶^Tarnopolsky M, Cupido C Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers J Appl Physiol (1985).(2000 Nov)

⁷Nehlig A, Daval JL, Debry G Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev.(1992)

⁸Christopher J Derry, Sheena Derry, R Andrew Moore Caffeine as an analgesic adjuvant for acute pain in adults Cochrane Database Syst Rev.(2014 Dec 11)