FlexBone Forte

FlexBone Forte, from Vitobest®, it is a synergistic formula of the latest generation with hydrolyzed collagen peptides (Fortibone® Bioactive Collagen Peptides®) (GELITA), MenaQ7® (vitamin K2), BCAA, organic silicon (bamboo extract), calcium and magnesium bisglycinate (Albion™) and vitamins C and D3 that work together to aid in the recovery of bone and bone mass.

Collagen, the most abundant protein in the body.

Collagen is the main component of connective tissue and the most abundant protein in the body (30%).

The bone specifically contains a large amount (25%) of type I and III collagen.

Bioactive peptides for maximum efficacy.

Most collagen supplements on the market are composed of hydrolyzed collagen which has very low absorption, slow and bothersome digestion, and little ability to act on specific structures, bones, joints or muscles, having a very reduced efficacy.

FlexBone Forte, from Vitobest®, incorporates bioactive peptides (Fortibone® Bioactive Collagen Peptides®) (GELITA) of the latest generation that act directly by stimulating the production and regeneration of the bone collagen matrix. These peptides are characterized by a specific molecular weight profile, and with proven optimal stimulation in specific cells¹.

Maximum digestibility due to its helical peptide form³, achieving maximum absorption and bioavailability².

Triple action pathway on specific cells¹.

Due to their specific composition, bioactive peptides act on target cells (bone, cartilage, muscles or tendons), in three phases, compared to the two phases of common hydrolysates:

1. Stimulating the cell.
2. RNA translation.
3. Biosynthesis of the extracellular matrix.

FlexBone Forte Vitobest®, a formula that hits the bullseye directly.

Not all collagen supplements are the same and their effectiveness directly depends on reaching and stimulating the correct structures and cells. The specific formula of FlexBone Forte it directly stimulates osteoclasts and osteoblasts, contributing to their regeneration and reducing bone degradation and loss of bone mass.

FlexBone Forte Vitobest® stimulates the synthesis of bone collagen matrix⁴.

Specific peptides Fortibone® they help stimulate bone cells to increase the synthesis of bone components such as collagen. They have a kind of "signaling effect" on osteoblasts to counteract the degradation of collagen in the extracellular bone matrix, which is the essential framework for bone mineralization.

Additionally, Fortibone® it positively influences degenerative processes in the bones by reducing the activity of osteoclasts. The result is a considerably higher synthesis of collagen bone matrix.

Bones need more than calcium.

Calcium supplements are everywhere, yet more and more people are suffering from osteoporosis and osteopenia. Bone is a mixture of mineral crystals contained in an organic collagen matrix⁴.

On their own, crystals would be extremely fragile and prone to breaking. The collagen in bones is essential for providing flexibility and elasticity to the bones.

Osteoporosis (OP) is a condition characterized by low bone mass and deterioration of the microarchitecture of bone tissue, leading to increased bone fragility and the consequent increased risk of fracture.

Maximum efficiency.

The advanced formula of FlexBone Forte it works by helping to improve bone metabolism, contributing to the recovery of bone mass and reducing its loss.

• Fortibone®: bioactive collagen peptides that directly stimulate the bone collagen matrix.
• MenaQ7® (vitamin K2): contributes to increasing the production of osteocalcin. Much of bone health is determined by a delicate balance between the formation and destruction of tissue by osteoblasts and osteoclasts and largely depends on vitamin K2⁶.
• BCAA: contributes to stimulating the production and fixation of cartilage in the bone matrix.
• Organic silicon (bamboo extract): provides organic silicon and minerals that significantly contribute to bone health.
• Calcium and Magnesium bisglycinate: indispensable for bone remineralization.
• Vitamin C: helps to improve collagen fixation.
• Vitamin D: indispensable for the absorption of calcium by the bone.

Benefits of FlexBone Forte Vitobest®:

• Helps to increase bone density.
• Helps stimulate the formation of collagen in the bone.
• Helps improve bone metabolism.
• Contributes to the production of osteocalcin enhanced by the MenaQ7®.
• Contributes to preventing bone mass loss.
• Very pleasant taste and effectiveness with lower doses.
• Presentation in sachets that facilitate transportation and intake.

Backed by scientific studies⁵.

A study has demonstrated the effectiveness of Fortibone® where significant positive changes were found in the bone mass density in the spinal column and femoral neck of the participants, confirmed through DXA scans.

The results showed a pronounced increase in BMD (bone mineral density) after supplementation. Fortibone® in women who suffer from osteopenia or osteoporosis. The results indicate that Fortibone® it is an interesting option to counteract bone degeneration.

FlexBone Forte, from Vitobest®, it comes in a convenient box format with 22 sachets of 15 g.

Bibliography:

¹Interaction of the α2A domain of integrin with small collagen fragments. Hans-Christian Siebert, Monika Burg-Roderfeld, Thomas Eckert, Sabine Stötzel, Ulrike Kirch, Tammo Diercks, Martin J. Humphries, Martin Frank, Rainer Wechselberger, Emad Tajkhorshid, Steffen Oesser.

²Srivastava 2017 p.457; Miner-Williams et al. 2014; Wada and Lönnerdal 2014 and Lorkowski 2012.

³Composition and properties of peptides that survive standardized in vitro gastro-pancreatic digestion of bovine milk. Davide Tagliazucchi, Ahmed Helal, Elena Verzelloni, Andrea Bellesia, Angela Conte.

⁴Alves Rd, Demmers JA, Bezstarosti K, Van der Eerden BC, Verhaar JA, Eijken M, Van Leeuwen P (2011). Unraveling the human bone microenvironment beyond classical extracellular matrix proteins: a library of human bone proteins. J proteome res 10: 4725-4733.

⁵Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study by Daniel König, Steffen Oesser, Stephan Scharla, Denise Zdzieblik and Albert Gollhofer.

⁶Knapen M. H. J., N. E. Drummen, E. Smit, C. Vermeer, E. Theuwissen. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507.