GlucoBest

GlucoBest, from Vitobest®, it is a formula combined with the most advanced and effective natural active ingredients to help control blood sugar (glucose).

Importance of blood sugar control.

The vast majority of the cells of our body use glucose as energy fuel, being especially important for our brain which consumes almost 6 mg of it per 100 g of tissue.

We should always have a certain amount of glucose circulating in our blood. and your levels are normal when fasting we have between 70 and 110 mg/dL. Below these levels, it is considered hypoglycemia and above, hyperglycemia or very high blood glucose.

Hyperglycemia is consequent in many pathologies and is really harmful in the medium and long term:

• It is the main cause of cardiovascular diseases.
• It causes neuropathies and retinopathies.
• It negatively affects blood clotting, increasing the risk of strokes and myocardial infarctions.
• It increases insulin resistance, being the main cause of obesity and diabetes.
• Hyperglycemia increases oxidative levels in the mitochondria, being the main cause of the oxidative stress cycle⁶.

GlucoBest, from Vitobest®, effectively contributes to controlling sugar levels naturally and effectively.

Active Ingredients GlucoBest:

Gymnema sylvestre.

In Indian culture, the properties of gymnema are known when its leaves are chewed, causing the sweet taste of food to not be perceived. Because of this property, gymnema is known in India as gurmar, which means "sugar destroyer" in Hindu.¹. It is one of the most studied plants and it has been shown that the administration of gymnema reduces blood glucose levels. Its effectiveness in patients with type I and II diabetes has also been demonstrated^1,2.

Berberis aristata (98% berberine).

Berberine is capable of reducing circulating glucose levels and also glycosylated hemoglobin levels³, a biochemical parameter that aids in the management and control of the development of diabetes or prediabetes, as it indicates the average of circulating glucose levels from the last 3 months. Berberine increases the activity of adiponectin.⁴ and improves peripheral sensitivity to insulin, so there is an increase in cellular glucose uptake. In summary, berberine is very effective in the treatment of hypoglycemia and also for insulin resistance.

Alpha lipoic acid (R-ALA) (Alipure®).

Alpha lipoic acid is a naturally occurring compound that plays an essential role in mitochondrial bioenergetic reactions (inside the cell), and is the subject of numerous studies as an antioxidant for its use in the management of diabetic complications. Lipoic acid is a very powerful antioxidant.⁵, acts on free radicals (ROS), chelates metal ions and reduces the oxidized forms of other antioxidants such as vitamin C, vitamin E and glutathione⁵. It also increases the antioxidant defense system. An important function is to activate the AMPK pathway in skeletal muscles⁵, which in turn have a large number of metabolic consequences.

Dry cinnamon extract 5:1.

The major components with pharmacological activity are cinnamaldehyde and type A procyanidin polymers⁷. It is believed that these compounds improve insulin sensitivity through better glucose uptake⁸ and glycogen synthesis⁷. Cinnamon has been proven to be effective in lowering blood sugar levels in patients diagnosed with type II diabetes⁸.

Chromium (Chromax® chromium picolinate).

As a trace element, this element is involved in the regulation of blood glucose.⁹. Its deficiency causes a deterioration of glucose metabolism due to poor insulin efficiency⁹.

Vitobest® used for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Product Claims:

• Chromium contributes to maintaining normal blood glucose levels.

Bibliography:

¹Neelakantan N, Narayanan M, de Souza RJ, Van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J. 2014;13:17. doi:10.1186/1475-2891-13-7

²Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990;30(3):295-300. doi: 10.1016/0378-8741(90)90108-6

³BERBERIS ARISTATA: A REVIEW by Sharma Komal*, Bairwa Ranjan, Chauhan Neelam, Shrivastava Birendra, Saini Neeraj Kumar from the School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India.

⁴Berberine Improves Insulin Sensitivity by Inhibiting Fat Storage and Adjusting Adipokine Profile in Human Preadipocytes and Metabolic Syndrome Patients Jing Yang,1 Jinhua Yin,1, 2 Hongfei Gao,1 Linxin Xu,1, 2 Yan Wang,1 Lu Xu,2 and Ming.

⁵Diabetes and Alpha Lipoic Acid. Saeid Golbidi, Mohammad Badran and Ismail Laher *Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

⁶Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H. P., Giardino, I., and Brownlee, M. (2000). Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 404, 787–790.

⁷Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung DO. Use of cinnamon in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med. 2013;11(5):452–459. doi:10.1370/afm.1517

⁸Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26(12):3215-3218. doi:10.2337/diacare.26.12.3215

⁹Anderson R. Chromium as an Essential Nutrient for Humans. Regulatory Toxicology and Pharmacology 1997; 26:S35-S41.